GI Manifestations of Cystic Fibrosis

CF affects multiple organ systems, with gastrointestinal manifestations playing a significant role in morbidity and mortality – and impacting quality of life. This talk by pediatric gastroenterologist Jennifer Duong, MD, aims to help clinicians respond appropriately to neonatal screening results (and know their limitations); pick up on signs of pancreatic, liver and digestive tract complications; and better understand therapeutic options, such as the CFTR modulators that are revolutionizing CF treatment while carrying serious short- and long-term risks. She also discusses racial disparities in this global disease and offers resources for doctors and families.

Learning Objectives:

• Recognize the benefits and limitations of tools used for CF neonatal screening and diagnosis.
• Identify and treat the most common gastrointestinal, hepatobiliary, and pancreatic complications of CF.
• Recognize that CF care in childhood may change in the setting of highly effective CFTR [cystic fibrosis transmembrane conductance regulator] modulator therapy.
• Consider how racial disparities exist for patients and that more diagnostic tools and therapies are needed for uncommon CFTR mutations.