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UCSF NCNC (Northern California Neonatology Consortium)
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Background:
Congenital hypothyroidism (CH) is one of the most preventable causes of intellectual disability. Newborn screening (NBS) enables early detection and treatment by identifying infants with elevated thyroid-stimulating hormone (TSH) levels within the first 24 to 48 hours of life. However, in infants who are preterm or have congenital heart disease, the rise in TSH may be delayed, necessitating a second screening after the initial NBS.
Patient criteria (any of the following):
- Birth GA < 32 weeks
- BW < 1500 grams
- All infants with congenital heart disease regardless of gestational age
Screening and Evaluation:
Clinically examine all patients for signs and symptoms of hypothyroidism: large posterior fontanelle, large tongue, umbilical hernia, prolonged jaundice, constipation, and/or hypothermia.
UCSF Multi-Site Neonatology Collaboration. Originated: 9/2025
