Demystifying the MABs: Immunomodulators for the Treatment of Rheumatic Conditions

In this tip-filled talk for pediatricians, pediatric rheumatologist Erica Lawson, MD, describes steps for evaluating children with signs of such conditions as juvenile arthritis and lupus, using case examples to illustrate physical exam clues, use of lab and imaging tests, and first treatment steps. She breaks down the disease-modifying anti-rheumatic drugs, with a focus on monoclonal antibodies, explaining specific pros, cons and caveats for the latest options. Included are pointers on recognizing macrophage activation syndrome and on handling an immunosuppressed kid with a fever.

Learning Objectives:

• Distinguish between biologic and non-biologic immunomodulators
• Develop an approach to immunosuppression for the management of juvenile idiopathic arthritis (JIA), taking into account family needs, culture and preferences
• Develop an approach to immunosuppression for the management of systemic lupus erythematosus (SLE), taking into account family needs, culture and preferences